Murine helper T lymphocyte response to influenza virus: recognition of haemagglutinin by subtype-specific and cross-reactive T cell clones
Identifieur interne : 002431 ( Main/Exploration ); précédent : 002430; suivant : 002432Murine helper T lymphocyte response to influenza virus: recognition of haemagglutinin by subtype-specific and cross-reactive T cell clones
Auteurs : Jacqueline M. Katz [Australie] ; Lorena E. Brown [Australie] ; Rosemary A. Ffrench [Australie] ; David O. White [Australie]Source :
- Vaccine [ 0264-410X ] ; 1985.
English descriptors
- Teeft :
- Antibody response, Assay, Cell clone, Cell clones, Cell determinants, Cell line, Cell lines, Clone, Culture medium, Determinant, Different subtypes, Different type, Haemagglutinin, Helper, Immunol, Influenza, Influenza virus, Influenza virus haemagglutinin, Influenza viruses, Katz, Monoclonal antibodies, Proliferation assays, Proliferative, Proliferative response, Same subtype, Spleen, Spleen cells, Subtypes, Various doses, Virus.
Abstract
Abstract: Helper T cell lines specific for influenza virus were established by continuous culture of Mem 71-Bel (H3) virus-immune spleen cells in the presence of virus and antigen-presenting cells and their specificity assessed in proliferation experiments. At line stimulated in vitro with Mem 71-Bel virus was able to proliferate in response to viruses of the same, and also of different, type A haemagglutinin (HA) subtypes as the immunizing virus but not to a type B influenza virus. A component of this cross-reactivity was due to recognition of the HA molecule. Lines stimulated in vitro with purified disrupted H3 or H2 viruses showed a higher degree of cross-reactivity. Of nine clones isolated from these lines, seven were directed against the HA molecule and recognized the HA1 chain. The HA-specific T cell clones were either subtype-specific, recognizing only viruses of the H3 subtype, or cross-reactive, also recognizing viruses of the H2 subtype of type A (but not type B). Subtype-specific and cross-reactive T cell clones were shown to function as helper T cells in vitro. In addition to collaborating with H3 virus-primed B cells responding to H3 virus in culture, the cross-reactive T cell clone could also provide help for H2 virus-primed B cells making anti-HA antibody in response to H2 virus.
Url:
DOI: 10.1016/0264-410X(85)90118-5
Affiliations:
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Brown</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, University of Melbourne, Parkville, Victoria 3052</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Ffrench, Rosemary A" sort="Ffrench, Rosemary A" uniqKey="Ffrench R" first="Rosemary A." last="Ffrench">Rosemary A. Ffrench</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, University of Melbourne, Parkville, Victoria 3052</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="White, David O" sort="White, David O" uniqKey="White D" first="David O." last="White">David O. White</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, University of Melbourne, Parkville, Victoria 3052</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Vaccine</title><title level="j" type="abbrev">JVAC</title><idno type="ISSN">0264-410X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="257">257</biblScope><biblScope unit="page" to="262">262</biblScope></imprint><idno type="ISSN">0264-410X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antibody response</term><term>Assay</term><term>Cell clone</term><term>Cell clones</term><term>Cell determinants</term><term>Cell line</term><term>Cell lines</term><term>Clone</term><term>Culture medium</term><term>Determinant</term><term>Different subtypes</term><term>Different type</term><term>Haemagglutinin</term><term>Helper</term><term>Immunol</term><term>Influenza</term><term>Influenza virus</term><term>Influenza virus haemagglutinin</term><term>Influenza viruses</term><term>Katz</term><term>Monoclonal antibodies</term><term>Proliferation assays</term><term>Proliferative</term><term>Proliferative response</term><term>Same subtype</term><term>Spleen</term><term>Spleen cells</term><term>Subtypes</term><term>Various doses</term><term>Virus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Helper T cell lines specific for influenza virus were established by continuous culture of Mem 71-Bel (H3) virus-immune spleen cells in the presence of virus and antigen-presenting cells and their specificity assessed in proliferation experiments. At line stimulated in vitro with Mem 71-Bel virus was able to proliferate in response to viruses of the same, and also of different, type A haemagglutinin (HA) subtypes as the immunizing virus but not to a type B influenza virus. A component of this cross-reactivity was due to recognition of the HA molecule. Lines stimulated in vitro with purified disrupted H3 or H2 viruses showed a higher degree of cross-reactivity. Of nine clones isolated from these lines, seven were directed against the HA molecule and recognized the HA1 chain. The HA-specific T cell clones were either subtype-specific, recognizing only viruses of the H3 subtype, or cross-reactive, also recognizing viruses of the H2 subtype of type A (but not type B). Subtype-specific and cross-reactive T cell clones were shown to function as helper T cells in vitro. In addition to collaborating with H3 virus-primed B cells responding to H3 virus in culture, the cross-reactive T cell clone could also provide help for H2 virus-primed B cells making anti-HA antibody in response to H2 virus.</div></front></TEI><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name></region><name sortKey="Brown, Lorena E" sort="Brown, Lorena E" uniqKey="Brown L" first="Lorena E." last="Brown">Lorena E. Brown</name><name sortKey="Ffrench, Rosemary A" sort="Ffrench, Rosemary A" uniqKey="Ffrench R" first="Rosemary A." last="Ffrench">Rosemary A. Ffrench</name><name sortKey="White, David O" sort="White, David O" uniqKey="White D" first="David O." last="White">David O. White</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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